Micro Silica Powder for Medical Use

                                                                     Micro Silica Powder for Medical Use

Micro powder silicone, also known as silica, is also known as White Carbon Black. The molecular formula is SiO2 · nH2O

Micro powder silica gel is a white powder with good fluidity, high purity, and no pollution. It has the characteristics of small particle size, large specific surface area, and multiple pores. At the same time, the surface distribution of silicon hydroxyl groups gives it good adsorption performance. In the pharmaceutical field, micro precipitated silica  is a very useful pharmaceutical excipient and an excellent flow promoter in the tablet production process. It can greatly improve particle fluidity, increase bulk density, increase the hardness of the prepared tablets, shorten the disintegration time, and thus improve the drug dissolution rate. In addition, micropowder silica gel is very suitable for traditional Chinese medicine enterprises to use in traditional Chinese patent medicines and simple preparations extracts due to its characteristics of absorbing water and promoting flow. Its application in pharmaceutical preparations has attracted more and more attention.

The advantages of micro powder silicone

1) It is a single inorganic compound with stable chemical and physical properties, and will not react with the main components in drug formulations, ensuring the therapeutic effect of the drug;

2) Has good water absorption, which can shorten the disintegration time of drugs without affecting the formation of the formulation;

3) Free of starch and protein, the formulation will not mold and cause drug failure;

4) It can be separated separately during drug formulation analysis, without interfering with conventional volumetric analysis, visible ultraviolet spectrophotometry, chromatographic analysis, and even ion spectrum analysis, which affects the accuracy of the analysis;

5) During the metabolic process of drugs, they are excreted in their original form and not absorbed by metabolism, ensuring that adverse drug reactions are minimized.

Multi faceted application of micro silica gel in formulations

Micro silica powder  is used as a lubricant and flow aid in the pharmaceutical industry. Lubricants can reduce the friction of the die, increase the sliding properties of particles, make it well filled, distribute the tablet density evenly, and also ensure the integrity of the tablet being ejected. The flow aid reduces the friction between particles, increases fluidity, and can meet the requirements of rapid and uniform filling for high-speed rotating tablet presses, while also ensuring that the weight difference meets the requirements.

In pharmaceutical manufacturing, it is mainly used as a disintegrant, anti sticking agent, and flow aid to improve the dissolution rate of drugs. In the manufacturing of granules, it can be used as an internal desiccant to enhance the stability of drugs. It is also one of the microcapsule materials. Adding it to the microcapsule can increase its density and specific surface area, enhance its fluidity. Micro powdered silica gel can also be used as a filter aid, clarifier, defoamer, as well as a suspension aid and thickener for liquid formulations.

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